Liverpool ripped apart Manchester City with three goals inside the opening 31 minutes as they won their Champions League quarter-final, first leg tie 3-0 on Wednesday.
Tottenham Hotspur scored a 2-0 victory at Manchester City, whilst Arsenal posted a 3-2 victory at Blackburn Rovers.
The result left the top positions in the Premier League unchanged. Arsenal lead the standings with 47 points, followed by Manchester United (45).
Arsenal and Manchester United will be out to make amends after a weekend of damaging results when they meet at The Emirates in the Premier League on Wednesday.
Liverpool, who are fifth in the table and have won just one league game since the turn of the year, host fourth-placed Arsenal on Saturday looking to bounce back immediately from one of their worst performances of the season.
Liverpool will attempt to sweep away the January blues on the last day of a wretched month when they host commanding Premier League leaders Chelsea at Anfield on Tuesday.
Chelsea's Didier Drogba proved Arsenal's nemesis again on Sunday when he scored the opening goal in the champions' 2-0 win over their London rivals which stretched their lead at the top of the Premier League. Blackpool also had an afternoon to remember, with a shock 2-1 win at Liverpool, which left Roy Hodgson's mis-firing side in the bottom three.
Arsenal joined Manchester United and Liverpool on the FA Cup scrapheap on Sunday when Ricardo Fuller's double helped Stoke City to a 3-1 fourth round victory at the Britannia Stadium.
Images from the English Premier League matches played on Saturday
Liverpool regained their place at the top of the English Premier League with a 2-0 win at Cardiff City on Sunday that restored their two-point lead over Manchester City
Wayne Rooney scored twice to help Manchester United stretch their unbeaten run to 12 games in an entertaining 2-2 Premier League draw at Tottenham Hotspur and Liverpool were upset 3-1 at HullCity on Sunday.
A round-up of the soccer matches played accross Europe over the weekend.
Julio Baptista scored three times as Arsenal stormed back to draw 2-2 with north London rivals Tottenham Hotspur in a frenetic first leg of their League Cup semi-final at White Hart Lane on Wednesday.
Chelsea moved two points clear at the top of the Premier League with a 2-0 defeat of Liverpool at Stamford Bridge on Sunday.
Arsenal's Jack Wilshere and Kieran Gibbs are doubtful for the Champions League Group F trip to last season's runners-up Borussia Dortmund with coach Arsene Wenger eager to make amends for last month's loss to the Germans.
A night of wholesale team changes for the 11 Premier League sides in action produced one notable upset with top flight Stoke City losing 2-0 at second-tier Bristol City.
Daniel Sturridge's third goal in as many matches gave Liverpool a 1-0 win over bitter rivals Manchester United in a feisty Premier League match at Anfield on Sunday.
Juergen Klopp refused to rule out Liverpool as Premier League title contenders on Wednesday after ending the year level on points with Manchester United and nine behind leaders Arsenal.
Holders Manchester City beat Chelsea 1-0 with a late Bernardo Silva goal on Saturday to reach the FA Cup final after an absorbing end-to-end Wembley semi-final left the exhausted winners still chasing a domestic double.
The result leaves Ole Gunnar Solskjaer's United in 10th with nine points, their worst start after seven games for 30 years, and they have won just one of their last six league games.
Nicolas Anelka scored twice against his old club to help Bolton Wanderers beat Arsenal 3-1 to climb to third in the Premier League on Saturday.
Images from Saturday's action in the Premier League.
Arsenal will begin their quest to become the first team in modern times to win the FA Cup three years running with a home tie against fellow Premier League side Sunderland in January.
Images from the English Premier League matches played on Saturday
Watford climbed into the top four of the Premier League after Tom Cleverley's 92nd-minute goal gave them a 2-1 victory over Arsenal at Vicarage Road on Saturday.
Tottenham Hotspur fluffed their last-day lines with a 5-1 defeat at relegated, 10-man Newcastle United that left them third in the Premier League behind bitter north London rivals Arsenal.
Newcastle United made light work of north-east rivals Sunderland as Alexander Isak's double secured a 3-0 win and a place in the FA Cup fourth round at the Stadium of Light on Saturday.
Chelsea and Liverpool maintained their unbeaten starts to the season and kept the pressure on early pace-setters Arsenal when they both chalked up 2-0 away wins in the Premier League on Saturday.
Arsenal laboured to their second win of the season with a highly-charged 1-0 victory against 10-man Newcastle United at St James' Park on Saturday.
Images from the English Premier League matches played on Tuesday.
Arsenal missed the chance to heighten the congestion at the top of the Premier League and suffered fresh injury blows when a frustrating 1-1 draw at Norwich City failed to take them alongside leaders Manchester City and Leicester City on Sunday.
Premier League leaders Liverpool stumbled again at home on Saturday, needing two Steven Gerrard goals to salvage a point in a 2-2 draw with Hull City.
Arsenal and Galatasaray are facing disciplinary action after supporters of the Turkish club lit red flares and threw them onto the pitch, briefly holding up play, in their Champions League group match on Wednesday.
Midfielder Jordan Henderson's fluke second-half goal kept Liverpool firmly in contention.
Liverpool's wide range of goalscorers this season is a direct result of their attacking style, according to manager Juergen Klopp.
Arsenal play away to City on Wednesday hoping to regain their grip on the title race after securing draws in their last three games.
Liverpool's Mohamed Salah ended his Premier League goal drought in style by scoring twice as the champions raided the capital again to crush West Ham United 3-1 on Sunday.
Liverpool are determined to end the trend of selling their best players during the close season in order to build a squad capable of consistently challenging for major honours, manager Juergen Klopp said.